Gonzalez RD, Small GW, Green AJ, Akhtari FS, Havener TM, Quintanilha JCF, Cipriani AB, Reif DM, McLeod HL, Motsinger-Reif AA, Wiltshire T. RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients. Pharmaceuticals. 2023; 16(5):726. https:…
Blog posts : "gxe"
Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure (2022) Toxics
Thunga P, Truong L, Rericha Y, Du J, Morshead M, Tanguay RL, Reif DM. Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure. Toxics. 2022 Dec 9;10(12):769. doi: 10.3390/toxics10120769. PMID: 36548602; PMCID: PMC9781692.
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Preethi successfully defends her PhD dissertation!!!
Preethi Thunga successfully defended her PhD dissertation, entitled 'Using zebrafish behavior to study gene-environment interactions after chemical exposures".
Retreat and student exchange with Tanguay Lab
Following a joint scientific retreat with Robyn Tanguay's group at Oregon State University (Including a beautiful waterfall hike!), they generously hosted Preethi Thunga at SARL so that she could gain better understanding of data generation for her dissertation work.
New NIH R01 grant awarded! "Characterizing Gene-Environment Interactions that Affect Individual Susceptibility to an Expanding Chemical Exposome"
Environmental chemical exposure has been linked to increases in cancer incidence, birth and developmental defects, impaired cognitive development, and neurodegenerative disease. However, even as the number of manufactured chemicals in the environment grows into the hundreds-of-thousands, comprehensi…
Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model (2022) Frontiers in Toxicology
Dylan James Wallis, Jane La Du, Preethi Thunga, Daniel Elson, Lisa Truong, Siva Kumar Kolluri, Robyn Leigh Tanguay, David M Reif. Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model. 29 April 2022. Fro…
The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior (2022) Toxicological Sciences
Shankar P, Garcia GR, LaDu JK, Sullivan CM, Dunham CL, Goodale BC, Waters KM, Stanisheuski S, Maier CS, Thunga P, Reif DM, Tanguay RL. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicol Sci. 2022 Apr 4:kfac037. doi: 10.1093/toxsci/kfac037. Epub ahead …
Preethi presents at SOT
Preethi presented a poster at the Society of Toxicology (SOT) annual meeting in San Diego:
"Using zebrafish behavior to reveal gene-environment interactions underlying population susceptibility differences after chemical exposure"
Preethi Thunga, Lisa Truong, Yvonne Rericha, Warren Anderson, …
Dylan presents at SOT
Dylan presented a poster at the Society of Toxicology (SOT) annual meeting in San Diego:
"Using High-throughput Screening to Identify Genetic Mechanisms of Individual Susceptibility Differences"
Dylan Wallis, Jane La Du, Preethi Thunga, Lisa Truong, Robyn L Tanguay, David M Reif
Dylan Wallis wins 3rd place or presentation at the NC Society of Toxicology annual meeting
Dylan Wallis won 3rd place at the NC Society of Toxicology annual meeting for their presentation "Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility DIfferences in a Genetically Diverse Zebrafish Model"
Extending the lymphoblastoid cell line model for drug combination pharmacogenomics (2021) Pharmacogenomics
Green AJ, Anchang B, Akhtari FS, Reif DM, Motsinger-Reif A. Extending the lymphoblastoid cell line model for drug combination pharmacogenomics. Pharmacogenomics. 2021 May 28. doi: 10.2217/pgs-2020-0160. Epub ahead of print. PMID: 34044623.
https://pubmed.ncbi.nlm.nih.gov/34044623/
Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions (2021) Toxics
Wallis DJ, Truong L, La Du J, Tanguay RL, Reif DM. Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions. Toxics. 2021; 9(4):77. https://doi.org/10.3390/toxics9040077
Abstract
Exposure to endocrine-disrupting che…
Farida's SOT abstract wins "Top 10" award from Computational Toxicology Speciality Section
Top 10 SOT-CTSS Abstract Awards Winner (Top 5% of all posters): F. Akhtari, G. Small, T. Havener, K. Roell, A. Green, J. House, D. Reif, H.McLeod, T. Wiltshire, A. Motsinger-Reif. High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genome cell lines reveals an assoc…
Farida's presentation wins Reviewer's Choice Award at ASHG Annual Meeting
Reviewers' Choice Award Winner (Top 10% of all posters):
F. Akhtari, G. Small, T. Havener, K. Roell, A. Green, J. House, D. Reif, H. McLeod, T. Wiltshire, A. Motsinger-Reif. High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genome cell lines reveals an associa…
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity (2020) Reproductive Toxicology
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity. Truong L, Marvel S, Reif DM, Thomas D, Pande P, Dasgupta S, Simonich MT, Waters KM, Tanguay RL.Reprod Toxicol. 2020 Aug 19:S0890-6238(20)30196-9. doi: 10.1016/j.reprotox.2020.08.007. Online ahead of print.PMID:…
Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines (2019) Frontiers in Genetics
Kyle Roell, Tammy Havener, David Reif*, John Jack, Howard McLeod, Tim Wiltshire, Alison Motsinger-Reif*
Front. Genet. | doi: 10.3389/fgene.2019.00829
Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines
Lymphoblastoid cell lines (LCL) are a high…
Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes (2019) Toxicol Appl Pharmacol
Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Aug 16;381:114711. doi: 10.1016/j.taap.2019.114711. [Epub ahead of print] PubMed P…
Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases (2019) Toxicology and Applied Pharmacology
Kosnik MB, Reif DM. Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases. Toxicol Appl Pharmacol. 2019 Jul 16:114674. doi: 10.1016/j.taap.2019.114674. [Epub ahead of print] PubMed PMID: 31323264.
Dr. Adrian Green joins the Reif Lab!
Dr. Adrian Green is a Postdoctoral Research Scholar in the Bioinformatics Research Center at NC State University. He received his Ph.D. in Toxicology at NC State University, and his M.S. in Pharmacology and Toxicology at the University of California, Davis. He received his B.S. in Microbiology (mino…
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