header photo

Blog posts : "gxe"

Preethi successfully defends her PhD dissertation!!!

Preethi Thunga successfully defended her PhD dissertation, entitled 'Using zebrafish behavior to study gene-environment interactions after chemical exposures".

 

 

Read more

Retreat and student exchange with Tanguay Lab

Following a joint scientific retreat with Robyn Tanguay's group at Oregon State University (Including a beautiful waterfall hike!), they generously hosted Preethi Thunga at SARL so that she could gain better understanding of data generation for her dissertation work.  

Read more

New NIH R01 grant awarded! "Characterizing Gene-Environment Interactions that Affect Individual Susceptibility to an Expanding Chemical Exposome"

Environmental chemical exposure has been linked to increases in cancer incidence, birth and developmental defects, impaired cognitive development, and neurodegenerative disease. However, even as the number of manufactured chemicals in the environment grows into the hundreds-of-thousands, comprehensi…

Read more

Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model (2022) Frontiers in Toxicology

Dylan James Wallis, Jane La Du, Preethi Thunga, Daniel Elson, Lisa Truong, Siva Kumar Kolluri, Robyn Leigh Tanguay, David M Reif. Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility Differences in a Genetically Diverse Zebrafish Model. 29 April 2022. Fro…

Read more

The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior (2022) Toxicological Sciences

Shankar P, Garcia GR, LaDu JK, Sullivan CM, Dunham CL, Goodale BC, Waters KM, Stanisheuski S, Maier CS, Thunga P, Reif DM, Tanguay RL. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Toxicol Sci. 2022 Apr 4:kfac037. doi: 10.1093/toxsci/kfac037. Epub ahead …

Read more

Preethi presents at SOT

Preethi presented a poster at the Society of Toxicology (SOT) annual meeting in San Diego:

"Using zebrafish behavior to reveal gene-environment interactions underlying population susceptibility differences after chemical exposure"

Preethi Thunga, Lisa Truong, Yvonne Rericha, Warren Anderson, …

Read more

Dylan presents at SOT

Dylan presented a poster at the Society of Toxicology (SOT) annual meeting in San Diego:

"Using High-throughput Screening to Identify Genetic Mechanisms of Individual Susceptibility Differences"

Dylan Wallis, Jane La Du, Preethi Thunga, Lisa Truong, Robyn L Tanguay, David M Reif

Read more

Dylan Wallis wins 3rd place or presentation at the NC Society of Toxicology annual meeting

Dylan Wallis won 3rd place at the NC Society of Toxicology annual meeting for their presentation "Leveraging a High-Throughput Screening Method to Identify Mechanisms of Individual Susceptibility DIfferences in a Genetically Diverse Zebrafish Model"

Read more

Extending the lymphoblastoid cell line model for drug combination pharmacogenomics (2021) Pharmacogenomics

Green AJ, Anchang B, Akhtari FS, Reif DM, Motsinger-Reif A. Extending the lymphoblastoid cell line model for drug combination pharmacogenomics. Pharmacogenomics. 2021 May 28. doi: 10.2217/pgs-2020-0160. Epub ahead of print. PMID: 34044623.

https://pubmed.ncbi.nlm.nih.gov/34044623/

Read more

David gives GGI seminar "Characterizing Gene-Environment Interactions in an Expanding Chemical Exposome"

The seminar series is part of the Genetics & Genomics Initiative.

 

Read more

Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions (2021) Toxics

Wallis DJ, Truong L, La Du J, Tanguay RL, Reif DM. Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions. Toxics. 2021; 9(4):77. https://doi.org/10.3390/toxics9040077

Abstract

Exposure to endocrine-disrupting che…

Read more

Farida's SOT abstract wins "Top 10" award from Computational Toxicology Speciality Section

Top 10 SOT-CTSS Abstract Awards Winner (Top 5% of all posters): F. Akhtari, G. Small, T. Havener, K. Roell, A. Green, J. House, D. Reif, H.McLeod, T. Wiltshire, A. Motsinger-Reif. High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genome cell lines reveals an assoc…

Read more

Farida's presentation wins Reviewer's Choice Award at ASHG Annual Meeting

Reviewers' Choice Award Winner (Top 10% of all posters):

F. Akhtari, G. Small, T. Havener, K. Roell, A. Green, J. House, D. Reif, H. McLeod, T. Wiltshire, A. Motsinger-Reif. High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genome cell lines reveals an associa…

Read more

The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity (2020) Reproductive Toxicology

The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity. Truong L, Marvel S, Reif DM, Thomas D, Pande P, Dasgupta S, Simonich MT, Waters KM, Tanguay RL.Reprod Toxicol. 2020 Aug 19:S0890-6238(20)30196-9. doi: 10.1016/j.reprotox.2020.08.007. Online ahead of print.PMID:…

Read more

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines (2019) Frontiers in Genetics

Kyle Roell, Tammy Havener, David Reif*, John Jack, Howard McLeod, Tim Wiltshire, Alison Motsinger-Reif*

Front. Genet. | doi: 10.3389/fgene.2019.00829

Synergistic chemotherapy drug response is a genetic trait in lymphoblastoid cell lines

Lymphoblastoid cell lines (LCL) are a high…

Read more

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes (2019) Toxicol Appl Pharmacol

Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA,
Rusyn I. Population-based toxicity screening in human induced pluripotent stem
cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Aug 16;381:114711. doi:
10.1016/j.taap.2019.114711. [Epub ahead of print] PubMed P…

Read more

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases (2019) Toxicology and Applied Pharmacology

Kosnik MB, Reif DM. Determination of chemical-disease risk values to
prioritize connections between environmental factors, genetic variants, and human
diseases. Toxicol Appl Pharmacol. 2019 Jul 16:114674. doi:
10.1016/j.taap.2019.114674. [Epub ahead of print] PubMed PMID: 31323264.

Dr. Adrian Green joins the Reif Lab!

Dr. Adrian Green is a Postdoctoral Research Scholar in the Bioinformatics Research Center at NC State University. He received his Ph.D. in Toxicology at NC State University, and his M.S. in Pharmacology and Toxicology at the University of California, Davis. He received his B.S. in Microbiology (mino…

Read more

NIH / NIEHS grant "Gene-Environment Interactions Causing Differential Susceptibility to Chemical Exposure in High-Throughput Screening"

Marissa Kosnik successfully defends her PhD!

Title - Data integration elucidates connections between environmental factors and health outcomes
 
Abstract : It is well understood that environmental factors contribute to the development of human diseases. Multiple types and sources of data are necessary to address the complex relationsh…

Read more

20 blog posts